Publications by authors named "J SAHL"
Background: Burkholderia pseudomallei, causative agent of melioidosis, is a One Health concern as it is acquired directly from soil and water and causes disease in humans and agricultural and wild animals. We examined B. pseudomallei in soil and goats at a single farm in the Northern Territory of Australia where >30 goats acquired melioidosis over nine years.
View Article and Find Full Text PDFWhole-genome sequencing of isolates from Native American gastric biopsy specimens.
Microbiol Resour Announc
September 2024
Article Synopsis
- Infection is associated with gastrointestinal diseases like gastric cancer, especially in indigenous populations in the U.S.
- High rates of infection and gastric cancer have been observed among Native Americans.
- This study involves whole-genome sequencing of three isolates from Native American patients suffering from gastric disease.
Genomic diversity in a pathogen population is the foundation for evolution and adaptations in virulence, drug resistance, pathogenesis, and immune evasion. Characterizing, analyzing, and understanding population-level diversity is also essential for epidemiological and forensic tracking of sources and revealing detailed pathways of transmission and spread. For bacteria, culturing, isolating, and sequencing the large number of individual colonies required to adequately sample diversity can be prohibitively time-consuming and expensive.
View Article and Find Full Text PDFArticle Synopsis
- - Leptospirosis, a disease caused by bacteria prevalent mostly in tropical areas, is transmitted through contact with infected rat urine or contaminated environments, with brown rats being key urban reservoirs.
- - A study conducted in Boston from 2016-2022 involved analyzing DNA from 328 rat kidney samples, revealing that 59 rats were positive for leptospirosis and indicating significant genetic structure and limited dispersal among rat populations.
- - The researchers discovered distinct genetic clades of the bacteria linked to specific rat groups, suggesting that rat movement influences the spread of leptospirosis, and indicated a connection between the disease in humans and urban rat populations based on genomic analysis.
Background: Pathogenic Leptospira species are globally important zoonotic pathogens capable of infecting a wide range of host species. In marine mammals, reports of Leptospira have predominantly been in pinnipeds, with isolated reports of infections in cetaceans.
Case Presentation: On 28 June 2021, a 150.