Publications by authors named "J S de Maar"
To investigate the feasibility and tolerability of ultrasound and microbubbles (USMB)-enhanced chemotherapy delivery for head and neck cancer, we performed a veterinary trial in feline companion animals with oral squamous cell carcinomas. Six cats were treated with a combination of bleomycin and USMB therapy three times, using the Pulse Wave Doppler mode on a clinical ultrasound system and EMA/FDA approved microbubbles. They were evaluated for adverse events, quality of life, tumour response and survival.
View Article and Find Full Text PDFPurpose: The aim of this study was to compare characteristics and survival of patients with de novo and metachronous metastatic breast cancer.
Methods: Data of patients with metastatic breast cancer were obtained from the Netherlands Cancer Registry. Patients were categorized as having de novo metastatic breast cancer (n = 8656) if they had distant metastases at initial presentation, or metachronous metastatic disease (n = 2374) in case they developed metastases within 5 or 10 years after initial breast cancer diagnosis.
The combination of ultrasound and microbubbles (USMB) has been applied to enhance drug permeability across tissue barriers. Most studies focused on only one physicochemical aspect (i.e.
View Article and Find Full Text PDFChemotherapy efficacy is often reduced by insufficient drug uptake in tumor cells. The combination of ultrasound and microbubbles (USMB) has been shown to improve drug delivery and to enhance the efficacy of several drugs and , through effects collectively known as sonopermeation. However, clinical translation of USMB therapy is hampered by the large variety of (non-clinical) US set-ups and US parameters that are used in these studies, which are not easily translated to clinical practice.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates an innovative method to enhance local delivery of doxorubicin for breast cancer treatment using Lyso-Thermosensitive Liposomal Doxorubicin (LTLD) combined with mild hyperthermia from Magnetic Resonance guided High-Intensity Focused Ultrasound (MR-HIFU).
- The primary focus is on 12 patients with stage IV HER2-negative breast cancer, aiming to determine the safety, tolerability, and feasibility of administering LTLD during MR-HIFU sessions.
- The study seeks to optimize local tumor control while minimizing systemic toxicity, potentially offering a less invasive treatment option for breast cancer patients who are chemotherapy-naïve.