ATTCT and ATTCC repeat expansions in the ATXN10 gene affect disease penetrance of spinocerebellar ataxia type 10.

Spinocerebellar ataxia type 10 (SCA10) is an autosomal-dominant disorder caused by an expanded pentanucleotide repeat in the gene. This repeat expansion, when fully penetrant, has a size of 850-4,500 repeats. It has been shown that the repeat composition can be a modifier of disease, e.

Robust Detection of Somatic Mosaicism and Repeat Interruptions by Long-Read Targeted Sequencing in Myotonic Dystrophy Type 1.

Myotonic dystrophy type 1 (DM1) is the most complex and variable trinucleotide repeat disorder caused by an unstable CTG repeat expansion, reaching up to 4000 CTG in the most severe cases. The genetic and clinical variability of DM1 depend on the sex and age of the transmitting parent, but also on the CTG repeat number, presence of repeat interruptions and/or on the degree of somatic instability. Currently, it is difficult to simultaneously and accurately determine these contributing factors in DM1 patients due to the limitations of gold standard methods used in molecular diagnostics and research laboratories.

The Complete Genome Sequence of , the Causal Agent of Canker on Tea Plants, Reveals Novel Secretion Systems in Clade-1 Xanthomonads.

is the causal agent of bacterial canker on tea plants. There is no complete genome sequence available for , a close relative of the species and , thus limiting basic research for this group of pathogens. Here, we release a high-quality complete genome sequence for the type strain, CFBP 4691.

High-Quality Genome Resource of Generated via Long-Read Sequencing.

The bacterial plant pathogen is the causal agent of yellow disease of and other ornamental plant genera. There is no available complete genome for , limiting basic research for this pathogen. Here, we release a high-quality complete genome sequence for the type strain, CFBP 1156.

Genomic Acquisitions in Emerging Populations of pv. Infecting Corn in the United States and Argentina.

pv. is an emerging bacterial plant pathogen that causes bacterial leaf streak on corn. First described in South Africa in 1949, reports of this pathogen have greatly increased in the past years in South America and in the United States.