Publications by authors named "J S Zacarias"
Background: A distinct phenotype in Coronavirus disease 2019 (Covid-19) was observed in severe patients, consisting of a highly impaired interferon (IFN) type I response, an exacerbated inflammatory response.
Objective: The aim of the present study was to investigate a possible association of single nucleotide polymorphisms (SNPs), in five genes related to the immune response, rs3775291 in ; rs2292151 in ; rs1758566 in ; rs1800629 in , and rs1800795 in with the severity of Covid-19.
Methods: A cross-sectional study was performed, with non-severe and severe/critical patients diagnosed with Covid-19, by two public hospitals in Brazil.
Four new HLA-B alleles were identified in Brazilian individuals using next generation sequencing.
View Article and Find Full Text PDFLow-cost molecular methodology for blood group antigens identification and genotyping contribution to transfusion efficacy in multiple transfused patients.
Expert Rev Mol Diagn
November 2022
Background: Blood transfusions usually result in the production of alloantibodies, complicating subsequent transfusions. Many blood group systems, in addition to ABO and Rh, can lead to the production of irregular antibodies in multiple transfused patients.
Objectives: The aim of this work was to standardize a molecular biology methodology for identified some alleles of KEL, FY, JK and DI blood group system; the transfusion efficacy of chronically transfused patients with phenotype-matched blood was also evaluated.
Article Synopsis
- Leprosy is a chronic disease and significant global health issue, with new cases reported annually; this study investigates genetic variants associated with susceptibility and protection against the disease.
- A case-control design involving 183 leprosy patients and 185 controls in southern Brazil was used to analyze specific genetic polymorphisms, identifying different frequencies in the control group that suggest a protective effect.
- Results indicate that certain genetic polymorphisms (such as rs5743618, rs1816702, and rs4696483) are linked to resistance or susceptibility to leprosy, highlighting the role of T and C alleles in influencing risk and protection.