Publications by authors named "J S Wolinsky"
Article Synopsis
- Evobrutinib, a BTK inhibitor, was evaluated for safety and efficacy against teriflunomide in treating relapsing multiple sclerosis in two phase 3 trials involving nearly 2,300 participants across 52 countries.
- Participants aged 18-55 with specific disability scores were randomly assigned to receive either evobrutinib or teriflunomide, with both studies designed as double-blind to avoid bias among participants and researchers.
- The primary endpoint was the annualized relapse rate over 156 weeks, with data collected from June 2020 to October 2023, showing that 66-67% of the participants were female across the trials.
Purpose: The objective of our study was to analyze methylomic and clinical features of a cohort of spinal meningiomas (SMs) resected at our institution.
Methods: This is a retrospective study of patients undergoing SM resection at our institution between 2010 and 2023. Clinical and radiographic characteristics were reviewed and analyzed with standard statistical methods.
Background And Objectives: Spinal chordomas are primary bone tumors where surgery remains the primary treatment. However, their low incidence, lack of evidence, and late disease presentation make them challenging to manage. Here, we report the postoperative outcomes of a large cohort of patients after surgical resection, investigate predictors for overall survival (OS) and local recurrence-free survival (LRFS) times, and trend functional outcomes over multiple time periods.
View Article and Find Full Text PDFIn addition to focal lesions, diffusely abnormal white matter (DAWM) is seen on brain MRI of multiple sclerosis (MS) patients and may represent early or distinct disease processes. The role of MRI-observed DAWM is understudied due to a lack of automated assessment methods. Supervised deep learning (DL) methods are highly capable in this domain, but require large sets of labeled data.
View Article and Find Full Text PDFArticle Synopsis
- People with multiple sclerosis (MS) often have anxiety, which can make their condition worse.
- Researchers wanted to see how a specific genetic score related to anxiety in people with MS.
- They found that having a higher genetic risk for anxiety was linked to more anxiety symptoms in MS patients, similar to those with anxiety alone.