Publications by authors named "J S Wisch"
Introduction: Alzheimer's disease (AD) in Down syndrome (DS) is associated with changes in brain structure. It is unknown if thickness and volumetric changes can identify AD stages and if they are similar to other genetic forms of AD.
Methods: Magnetic resonance imaging scans were collected for 178 DS adults (106 nonclinical, 45 preclinical, and 27 symptomatic).
Article Synopsis
- This case report discusses a pediatric patient with focal fibrocartilaginous dysplasia (FFCD) who experienced angular deformity and growth arrest, even with standard guided growth management.
- The patient initially underwent implant-mediated guided growth for correcting a proximal tibia varus deformity, but the issue recurred, leading to the identification of a physeal bar that resulted in complete physeal arrest.
- The report concludes that while treatment for FFCD-related angular deformity may involve observation and guided growth, there is a significant risk of complete physeal arrest that needs to be considered.
Article Synopsis
- - Development of Alzheimer's disease (AD) pathology occurs faster in individuals with Down's syndrome (DS) compared to others; this study focuses on comparing specific biomarkers in DS individuals and their siblings.
- - Researchers found that plasma levels of glial fibrillary acidic protein (GFAP) and pTau-217 were elevated in individuals with DS, indicating increased astrogliosis and tau pathology, and GFAP played a mediating role in the relationship between amyloid and tau levels.
- - The findings suggest that astrogliosis is crucial in the early stages of Alzheimer's in DS, and targeting neuroinflammation might be beneficial primarily for those with amyloid positivity.
Article Synopsis
- The study explores the relationship between traditional radiographic measurements of shoulder asymmetry and new surface topographic measurements, suggesting these relationships will be weak.
- Data was collected from a registry of patients with idiopathic scoliosis, focusing on ST scanning along with standard radiographic evaluation methods.
- Results showed that while the ST-based AC angle showed moderate-to-strong correlations with some radiographic measures, other ST measurements exhibited weak or no correlation, indicating a complex relationship between the two measurement types.
Introduction: Cerebrospinal fluid (CSF) tau phosphorylation at multiple sites is associated with cortical amyloid and other pathologic changes in Alzheimer's disease. These relationships can be non-linear. We used an artificial neural network to assess the ability of 10 different CSF tau phosphorylation sites to predict continuous amyloid positron emission tomography (PET) values.
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