Publications by authors named "J S Vanderheyden"
Article Synopsis
- - MRI with hyperpolarized (HP) C agents allows for the measurement of altered metabolism in various diseases, including cancers and organ diseases, and has seen increased application in human studies over the last decade due to improved preparation methods of HP agents.
- - This paper focuses on the use of [1-C]pyruvate, the most popular HP agent, and is organized into four main sections: agent preparation, MRI system setup, data collection, and analysis, highlighting essential components for effective studies.
- - The findings come from the "HP C MRI Consensus Group" and aim to provide a comprehensive guide for best practices, addressing both successful studies and existing gaps, while fostering future advancements in metabolic imaging.
MRI with hyperpolarized (HP) C agents, also known as HP C MRI, can measure processes such as localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, with recent rapid growth in studies largely based on increasing availability of hyperpolarized agent preparation methods suitable for use in humans. This paper aims to capture the current successful practices for HP MRI human studies with [1-C]pyruvate - by far the most commonly used agent, which sits at a key metabolic junction in glycolysis.
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- * Current assessments often rely on visual interpretation, but using precise quantitative SUV ratios allows for earlier detection of amyloid plaques and tracking of antiamyloid treatment effectiveness.
- * The Quantitative Imaging Biomarkers Alliance has established guidelines to reduce variability in measurements, leading to high statistical power for study conclusions and improved precision in clinical and research settings.
The present study aims to assess the clinical and hemodynamic impact of percutaneous edge-to-edge mitral valve repair with MitraClip in patients with atrial functional mitral regurgitation (A-FMR) compared with ventricular functional mitral regurgitation (V-FMR). Mitral regurgitation (MR) grade, functional status (New York Heart Association class), and major adverse cardiac events (MACE; all-cause mortality or hospitalization for heart failure) were evaluated in 52 patients with A-FMR and in 307 patients with V-FMR. In 56 patients, hemodynamic assessment during exercise echocardiography was performed before and 6 months after intervention.
View Article and Find Full Text PDFTime-driven activity-based costing (TDABC) has received considerable attention globally as a way to measure value in healthcare systems. This study aimed to apply TDABC for cataract surgery at the Kensington Eye Institute (KEI). During a field evaluation, a detailed process map was created for cataract surgery at KEI.
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