Chest Wall Injury Society recommendations for long-term follow-up after nonoperatively and operatively managed traumatic rib and sternal fractures.

Therapeutic/Care Management; Level IV.

A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden.

Engineered probiotics are an emerging platform for in situ delivery of therapeutics to the gut. Herein, we developed an orally administered, yeast-based therapeutic delivery system to deliver next-generation immune checkpoint inhibitor (ICI) proteins directly to gastrointestinal tumors. We engineered Saccharomyces cerevisiae var.

Characterizing the propagation evolution of optical vortex lattices in astigmatic transformations of frequency-doubled laser modes.

We develop a wave representation to characterize the propagation evolution of vortex lattice beams, which are produced through a frequency-doubling process of various high-order laser modes, followed by mode conversion. Their phase fields and phase gradients are further analyzed to verify the topological charge for each isolated vortex, as well as the symmetry and net charges of the vortex lattices. In the experiment, we demonstrate the generation of frequency-doubled high-order modes by utilizing an off-center pumped solid-state laser combined with intracavity second-harmonic generation.