Gedunin Mitigates -Induced Skin Inflammation by Inhibiting the NF-κB Pathway.

: , a bacterium residing in hair follicles, triggers acne by inducing monocyte-mediated inflammatory cytokine production. Gedunin, a limonoid derived from (commonly known as neem), is renowned for its antifungal, antimalarial, anticancer, anti-inflammatory, and neuroprotective effects. However, its role in mitigating -induced skin inflammation remains unexplored.

Fluid Resuscitation and Initial Management in Patients Presenting with Sepsis in the General Ward.

The optimal management of hospital-presenting sepsis remains poorly understood. We investigated the initial management in patients presenting with sepsis in the general ward, the association between fluid resuscitation and clinical outcomes, and the factors affecting fluid resuscitation. A retrospective study was conducted on patients who presented with sepsis-induced hypotension in the general ward.

Nurses' Clinical Decision-Making About Pressure Injury Prevention in Hospital Settings: A Scoping Review.

Aim: To systematically explore research on nurses' clinical decision-making and factors influencing pressure injury prevention in hospitalised patients.

Design: Scoping review.

Data Sources: Medline full text, Cumulative Index to Nursing and Allied Health Literature Plus with full text, and Scopus.

Disparities in Patient Demographics at a Student-Run Free Clinic: Comparing Clinic Utilization to City, State, and National Trends.

Background: With 8.4% of Americans uninsured, free clinics serve as essential safety nets for underserved populations. This study compared the demographics of the patients of a student-run free to Toledo, Ohio, and national census data to evaluate health needs, barriers to care, and the characteristics of the underserved population.

TBX3 is Essential for Zygotic Genome Activation and Embryonic Development in Pigs.

The pluripotency-related T-box family transcription factor TBX3 maintains mESC self-renewal and plays a key role in the development of several tissues, including the heart, mammary glands, limbs, and lungs. However, the role of TBX3 during porcine preimplantation embryo development remains unclear. In our research, TBX3 was knocked down by injecting dsRNA to explore the function of TBX3.