Publications by authors named "J S Sillah"
Article Synopsis
- - African countries are focusing on Universal Health Coverage (UHC), Health Security (HSE), and Coverage of Health Determinants (CHD) to improve health outcomes but face resource limitations, necessitating the prioritization of high-impact health interventions.
- - A review of 151 studies and 357 interventions revealed that the majority of effective health services target health promotion, disease prevention, and curative functions, with a notable emphasis on communicable diseases and lower representation of elderly interventions.
- - The findings resulted in a comprehensive list of effective health interventions that can be prioritized by decision-makers, along with principles for selecting interventions that maximize coverage and integrate various public health functions.
Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens. The adaptor protein Mal (also known as TIRAP), encoded by TIRAP (MIM 606252), mediates downstream signaling of TLR2 and TLR4 (refs. 4-6).
View Article and Find Full Text PDFThe sst1 locus has been identified in a mouse model to control resistance and susceptibility of Mycobacterium tuberculosis infection. Subsequent studies have now identified Ipr1 (intracellular pathogen resistance 1) to be the gene responsible. Ipr1 is encoded within the sst1 locus and is expressed in the tuberculosis lung lesions and macrophages of sst1-resistant, but not sst1-susceptible mice.
View Article and Find Full Text PDFRationale: Interferon-gamma (IFN-gamma) is of central interest in the study of tuberculosis. A number of single-gene mutations have been identified in the IFN-gamma signaling pathway that predispose to severe mycobacterial disease, but the relevance of polymorphism within these genes to the common phenotype of tuberculosis remains unclear.
Methods: A total of 1,301 individuals were included in a large, detailed study of West African populations with pulmonary tuberculosis.
Background: Host-related and environment-related factors have been shown to play a role in the development of tuberculosis (TB), but few studies were carried out to identify their respective roles in resource-poor countries.
Methods: A multicentre case-control study was conducted in Guinée, Guinea Bissau, and The Gambia, from January 1999 to March 2001. Cases were newly detected smear positive TB patients.