KdpD is a tandem serine histidine kinase that controls K pump KdpFABC transcriptionally and post-translationally.

Two-component systems, consisting of a histidine kinase and a response regulator, serve signal transduction in bacteria, often regulating transcription in response to environmental stimuli. Here, we identify a tandem serine histidine kinase function for KdpD, previously described as a histidine kinase of the KdpDE two-component system, which controls production of the potassium pump KdpFABC. We show that KdpD additionally mediates an inhibitory serine phosphorylation of KdpFABC at high potassium levels, using not its C-terminal histidine kinase domain but an N-terminal atypical serine kinase domain.

Glenohumeral internal rotation deficit in general population with shoulder pain: A descriptive observational study.

Glenohumeral internal rotation deficit (GIRD) is one of the most important factors influencing injury risk in the arm of overhead athletes. Some studies have shown that the GIRD of athletes with shoulder pain was higher than those without shoulder pain, establishing a relation between shoulder pain and GIRD. However, there are no studies that relate to GIRD and shoulder pain or the risk factors that affect GIRD in the population with this ailment.

Treatment of glenohumeral internal rotation deficit in the general population with shoulder pain: An open single-arm clinical trial.

Background: Maladaptation can provoke important alterations in the arthrokinematics such as an internal rotation reduction in the dominant shoulder compared with the nondominant shoulder known as glenohumeral internal rotation deficit (GIRD). Though the number of studies investigating GIRD in athletic population, there are not studies reporting the efficacy of the GIRD treatment in the nonathlete population, a kind of study required to improve our understanding of patient care with this pathology. This study aimed to describe the efficacy of the GIRD treatment in nonathlete population with shoulder pain.

Hybrid Cathode Lithium Battery Discharge Simulation for Implantable Cardioverter Defibrillators Using a Coupled Electro-Thermal Dynamic Model.

This paper explores the effect of the load imposed by implantable cardioverter defibrillators (ICDs) on their lithium battery power sources longevity using a simulation approach that incorporates a coupled electro-thermal dynamic model. ICDs are one of the effective treatments available to significantly improve survival of patients with fatal arrhythmia (abnormal heart rhythm) disorders. Using a lithium battery power source, this life-saving device sends electrical shocks or pulses to regulate the heartbeat.

Inhibited KdpFABC transitions into an E1 off-cycle state.

KdpFABC is a high-affinity prokaryotic K uptake system that forms a functional chimera between a channel-like subunit (KdpA) and a P-type ATPase (KdpB). At high K levels, KdpFABC needs to be inhibited to prevent excessive K accumulation to the point of toxicity. This is achieved by a phosphorylation of the serine residue in the TGES motif in the A domain of the pump subunit KdpB (KdpB).