Publications by authors named "J S Sheppard"
Background And Objective: People with adult-onset hearing loss (AoHL) are at increased dementia risk. In this study, we explore potential aetiological mechanisms by synthesising the evidence on the association between AoHL and neuropathological, cerebrospinal fluid (CSF), blood and imaging biomarkers of dementia.
Methods: We systematically searched electronic databases from inception to 30 April 2024 for cross-sectional and longitudinal studies, including quantitative data on the association between AoHL and dementia biomarkers.
Operant keypress tasks in a reinforcement-reward framework where behavior is shaped by its consequence, show lawful relationships in human preference behavior (i.e., approach/avoidance) and have been analogized to "wanting".
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- An international network is being developed to survey scientists continuously, gathering extensive datasets about their opinions over time.
- Local coordinators at participating institutions will send out brief survey invitations to scientists, utilizing a simple 10-second survey format with a single statement and a five-point Likert scale.
- A recent study successfully engaged over 20,000 scientists, receiving 6,807 responses, which demonstrates the feasibility of quickly measuring global scientific opinion, potentially aiding in policy-making and enhancing public understanding.
Purpose: This pooled analysis of two pivotal studies (ESSENCE-1 and ESSENCE-2) evaluated treatment effects of a water-free ciclosporin 0.1% solution in dry eye disease (DED) patients in the overall population and in subgroups according to sex, age, and baseline severity of disease.
Methods: In these randomized, multicenter, double-masked, vehicle-controlled studies patients received ciclosporin 0.
Background: Nocturnal home blood pressure monitoring (HBPM) may identify people at higher cardiovascular disease (CVD) risk than expected.
Objectives: The aim of this study was to examine the association between office-masked nocturnal hypertension, defined by HBPM, and CVD risk in a clinical practice-based population.
Methods: Prospective observational study including Japanese high cardiovascular-risk participants.