Publications by authors named "J S Schieffelin"
Introduction: Recent Rift Valley fever (RVF) epidemiology in eastern Africa region is characterized by widening geographic range and increasing frequency of small disease clusters. Here we conducted studies in southwestern (SW) Uganda region that has since 2016 reported increasing RVF activities.
Methods: A 22-month long hospital-based study in three districts of SW Uganda targeting patients with acute febrile illness (AFI) or unexplained bleeding was followed by a cross-sectional population-based human-animal survey.
Correction: A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)-Study protocol.
PLoS One
January 2025
[This corrects the article DOI: 10.1371/journal.pone.
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- The systematic review focuses on reproductive health issues faced by female survivors of Lassa fever and Ebola virus disease.
- Thirteen studies reviewed predominantly highlight negative outcomes related to reproductive health among EVD survivors, including menstrual irregularities and pregnancy loss, with no research identified on LF survivors.
- The analysis indicates that about 14% of female EVD survivors experience adverse reproductive health outcomes, revealing a significant need for further research in this area.
Article Synopsis
- - The study investigates how SARS-CoV-2 monoclonal antibody (mAB) therapy affects the immune response in five cancer patients infected with the virus, comparing them to non-mAB-treated controls.
- - Blood samples were analyzed for various immune responses, revealing that all patients produced antibodies and T-cell responses similar to those of controls, despite some having B-cell deficiencies.
- - The findings indicate that mAB therapy results in a robust immune response against SARS-CoV-2 in cancer patients, showing the potential for effective protective immunity even with underlying malignancies.
Background/objectives: Ebola virus disease (EVD) survivors develop post-acute ophthalmic sequelae, including a high prevalence of uveitis that may be complicated by vision-threatening cataract. After the non-detection of Ebola virus (EBOV) RNA in sampled ocular fluid, vision impairment due to cataract can be treated safely and effectively via manual small incision cataract surgery (MSICS). However, the long-term ocular visual outcomes and assessment of ocular tissues, including for genomic RNA, have been infrequently or not reported in Western African survivors.
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