Publications by authors named "J S Sarff"

Current-carrying, toroidal laboratory plasmas typically cannot be sustained with an electron density above the empirical Greenwald limit. Presented here are tokamak experiments in the Madison Symmetric Torus with a density up to an unprecedented level about 10 times this limit. This is thought to be made possible in part by a thick, stabilizing, conductive wall, and a high-voltage, feedback-controlled power supply driving the plasma current.

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This paper presents the development of an all-in-one probe to simultaneously measure all components of the generalized Ohm's law in reversed-field pinch plasmas and tokamaks. The polyhedral configuration of the Mach probe is achieved through the specific arrangement, angle, and depth of the collimator channel apertures drilled into the surface of a hollow boron nitride cylinder encasing it. This probe includes a central Mach probe to assess the ion velocity field in three dimensions.

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Measurements and simulations show that plasma relaxation processes in the reversed field pinch drive and redistribute both magnetic flux and momentum. To examine this relaxation process, a new 3D Mach B-dot probe has been constructed. This probe collects ion saturation currents through six molybdenum electrodes arranged on the flattened vertices of an octahedron made of boron nitride (BN).

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Article Synopsis
  • Duchenne muscular dystrophy (DMD) is primarily caused by mutations in the dystrophin gene, which can potentially be corrected using CRISPR-Cas9 technology.
  • A novel gene editing system was designed to deliver a DNA fragment containing a pre-spliced mega-exon into intron 19 via AAV vectors, achieving significant correction results in mice with a specific exon duplication.
  • This method successfully edited 1.4% of heart genomes and restored some dystrophin function, showing promise for treating approximately 25% of DMD patients with mutations before intron 19.
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A multi-energy soft x-ray pinhole camera has been designed, built, and deployed at the Madison Symmetric Torus to aid the study of particle and thermal transport, as well as MHD stability physics. This novel imaging diagnostic technique employs a pixelated x-ray detector in which the lower energy threshold for photon detection can be adjusted independently on each pixel. The detector of choice is a PILATUS3 100 K with a 450 μm thick silicon sensor and nearly 100 000 pixels sensitive to photon energies between 1.

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