Publications by authors named "J S Raskin"

Article Synopsis
  • Pleural mesothelioma (PM) is a rare and aggressive cancer often diagnosed late, highlighting the need for early detection biomarkers through DNA methylation analysis.
  • This study generated a large dataset comparing DNA methylation patterns between healthy pleura and PM, identifying over 81,000 differentially methylated sites, including five key sites linked to specific genes.
  • The findings indicate that PM has unique methylation profiles that distinguish it from other lung diseases and may aid in understanding the disease’s progression and offer potential for biomarker development.
View Article and Find Full Text PDF

Background: Intrathecal baclofen pump (ITBP) therapy has been successfully used to treat hypertonia in children with cerebral palsy (CP) since its Food and Drug Administration approval in 1984. CP affects multiple organ systems, leading to the accumulation of medical access and implantable devices, increasing the medical complexity of these children. The authors present the case of a patient with extreme surgical complexity and review the medical decision-making and surgical details.

View Article and Find Full Text PDF

Sirtuin 6 activation is a novel epigenetic mechanism proposed for treatment of depression. Two Phase 1 studies, SP-624-101 and SP-624-102, examined the pharmacokinetics and safety of SP-624, an orally active sirtuin 6 activator, in healthy adults. SP-624-101 was a single-ascending-dose study.

View Article and Find Full Text PDF

The neurophysiological mechanisms supporting brain maturation are fundamental to attention and memory capacity across the lifespan. Human brain regions develop at different rates, with many regions developing into the third and fourth decades of life. Here, in this preregistered study (https://osf.

View Article and Find Full Text PDF

Purpose: To provide consensus-based recommendations for use of vagus nerve stimulation (VNS) therapy in the management of pediatric epilepsy.

Methods: Delphi methodology with two rounds of online survey was used to build consensus. A steering committee developed 43 statements related to pediatric epilepsy and the use of VNS therapy, which were evaluated by a panel of 12 neurologists/neurosurgeons with expertise in pediatric epilepsy, who graded their agreement with each statement on a scale of 1 ("I do not agree at all") to 5 ("I strongly agree").

View Article and Find Full Text PDF