The global implications of a Russian gas pivot to Asia.

Recent years have seen unprecedented shifts in global natural gas trade, precipitated in large part by Russia's war on Ukraine. How this regional conflict impacts the future of natural gas markets is subject to three interconnected factors: (i) Russia's strategy to regain markets for its gas exports; (ii) Europe's push towards increased liquified natural gas (LNG) and the pace of its low carbon transition; and (iii) China's gas demand and how it balances its climate and energy security objectives. A scenario modelling approach is applied to explore the potential implications of this geopolitical crisis.

Clinical Manifestations.

Background: PET quantifies tau and amyloid-ß (Aß) pathology in preclinical AD. A 2-min digital clock-drawing test (DCTclock ) captures clock-drawing outcomes and processes, potentially more sensitive to cognitive deficits in preclinical AD than pencil-and-paper tests. The DCTclock summary score comprised subscores targeting multi-domain cognitive performance (i.

Abscopal Effect in a Patient With Metastatic Melanoma Receiving Hypofractionated Radiation Therapy and Dual Immune Checkpoint Inhibition: A Case Report.

Concurrent with the increasing utilization of immune checkpoint inhibitors (ICIs) in melanoma, there has been renewed interest in understanding the potential interplay between radiation therapy (RT) and the immune system. One such phenomenon is the abscopal effect, where localized treatments, such as RT, not only shrink the targeted tumor but also induce shrinkage of untreated tumors elsewhere in the body. Here, we report a case of an abscopal effect in a 63-year-old patient with metastatic melanoma who was progressing on first-line dual ICI therapy but experienced a rapid and durable systemic response following the administration of hypofractionated palliative RT to a large primary melanoma skin tumor.

Ubiquitin-mediated recruitment of the ATG9A-ATG2 lipid transfer complex drives clearance of phosphorylated p62 aggregates.

Autophagy is an essential cellular recycling process that maintains protein and organelle homeostasis. ATG9A vesicle recruitment is a critical early step in autophagy to initiate autophagosome biogenesis. The mechanisms of ATG9A vesicle recruitment are best understood in the context of starvation-induced non-selective autophagy, whereas less is known about the signals driving ATG9A vesicle recruitment to autophagy initiation sites in the absence of nutrient stress.

Primary Care Screening for Nonalcoholic Fatty Liver Disease Among People With HIV in the United States: A Real-World Provider Survey.

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in people with HIV (PWH) and increases the risk of hepatic fibrosis and hepatocellular carcinoma. We sent an online survey to providers of the American Academy of HIV Medicine. Of respondents (n = 214, 8% response rate), 65% reported screening for NAFLD in PWH, with 28% routinely screening all patients.