Publications by authors named "J S Pollak"
Brevetoxins are a type of neurotoxin produced in red tide blooms. Northern quahogs () are extensively used in commercial aquaculture farming, and early-stage metabolomics studies can provide early warnings of brevetoxins for farmers. In this study, NMR-based metabolomics was performed to investigate the response of clam gills and digestive glands under a series of sublethal doses of brevetoxins.
View Article and Find Full Text PDFTo propose criteria for retreating previously embolized PAVMs and determining the effectiveness of the criteria to prevent paradoxical embolization. A retrospective review of patients with PAVMs treated at a single HHT center of excellence between 1 January 2013, and 10 September 2023, was performed. Patients with PAVM recurrence were either retreated or observed based on the following criteria for PAVM reintervention: 1.
View Article and Find Full Text PDFArticle Synopsis
- Metabolomics is used to study metabolite changes in human diseases and the environment, but one-dimensional NMR (1D NMR) faces issues with overlapping peaks that hinder accurate analysis.
- This research developed an automated method using machine learning to process two-dimensional NMR (2D NMR) data, which overcomes the peak overlap problem present in 1D NMR.
- The study found that machine learning techniques like artificial neural networks achieved about 90% accuracy in peak selection, suggesting their strong potential for quantitative applications in 2D NMR-based metabolomics.
Community profiles in northeastern and central Pennsylvania characterized by distinct social, natural, food, and physical activity environments and their relation to type 2 diabetes.
Environ Epidemiol
October 2024
Background: Understanding geographic disparities in type 2 diabetes (T2D) requires approaches that account for communities' multidimensional nature.
Methods: In an electronic health record nested case-control study, we identified 15,884 cases of new-onset T2D from 2008 to 2016, defined using encounter diagnoses, medication orders, and laboratory test results, and frequency-matched controls without T2D (79,400; 65,069 unique persons). We used finite mixture models to construct community profiles from social, natural, physical activity, and food environment measures.
Mechanical Thrombectomy for High-Risk Pulmonary Embolism: Insights From the US Cohort of the FLASH Registry.
J Soc Cardiovasc Angiogr Interv
January 2024
Background: Acute mortality for high-risk, or massive, pulmonary embolism (PE) is almost 30% even when treated using advanced therapies. This analysis assessed the safety and effectiveness of mechanical thrombectomy (MT) for high-risk PE.
Methods: The prospective, multicenter FlowTriever All-comer Registry for Patient Safety and Hemodynamics (FLASH) study is designed to evaluate real-world PE patient outcomes after MT with the FlowTriever System (Inari Medical).