Synchronous activation of striatal cholinergic interneurons induces local serotonin release.

Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of CINs induces and extends the range of local serotonin release via a similar mechanism. This process is exaggerated in the hypercholinergic striatum of a mouse model of OCD-like behavior, implicating CINs as critical regulators of serotonin levels in the healthy and pathological striatum.

The evolution of private reputations in information-abundant landscapes.

Reputations are critical to human societies, as individuals are treated differently based on their social standing. For instance, those who garner a good reputation by helping others are more likely to be rewarded by third parties. Achieving widespread cooperation in this way requires that reputations accurately reflect behaviour and that individuals agree about each other's standings.

Convergence of reputations under indirect reciprocity.

Previous research has shown how indirect reciprocity can promote cooperation through evolutionary game theoretic models. Most work in this field assumes a separation of time-scales: individuals' reputations equilibrate at a fast time scale for given frequencies of strategies while the strategies change slowly according to the replicator dynamics. Much of the previous research has focused on the behaviour and stability of equilibria for the replicator dynamics.

The evolution of social behaviors and risk preferences in settings with uncertainty.

Humans update their social behavior in response to past experiences and changing environments. Behavioral decisions are further complicated by uncertainty in the outcome of social interactions. Faced with uncertainty, some individuals exhibit risk aversion while others seek risk.