Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice.

Background: Obesity and overweight are associated with low-grade inflammation induced by adipose tissue expansion and perpetuated by altered intestinal homeostasis, including increased epithelial permeability. Intestinal epithelium functions are supported by intestinal epithelial cells (IEC) mitochondria function.

Methods And Results: Here, we report that diet-induced obesity (DIO) in mice induces lipid metabolism adaptations favoring lipid storage in IEC together with reduced number, altered dynamics and diminished oxidative phosphorylation activity of IEC mitochondria.

Evaluating the Effects of Compound Stimuli on Stimulus Control during Match-to-Sample Procedures.

The use of compound stimuli in match-to-sample training arrangements can potentially increase the efficiency of target acquisition in some circumstances as a result of the development of emergent relations. However, utilizing compound stimuli in training arrangements comes with the risk that responding could come under the restrictive control of one of the individual components of the compound stimulus. The purpose of this case study was to demonstrate an evaluation process for determining the impact of compound stimuli on stimulus control within a match-to-sample arrangement.

Heparinized collagen-based hydrogels for tissue engineering: physical, mechanical and biological properties.

As the main protein forming the vascular extracellular matrix, collagen has a weak antigenicity, making it an attractive candidate for coatings of vascular grafts. In order to bring antithrombotic properties to collagen for obtaining suitable blood compatibility of surfaces and further bioactive molecule carrying capacity, heparinization appears as a method of choice. Thus, in this article, pH-driven self-assembly was used to form collagen-based hydrogels with physical incorporation of heparins, especially low molecular weight heparin or unfractionated heparin at 1 IU/mL and 6 IU/mL.