COVID-19 Vaccines Effectiveness and Safety in Trinidad and Tobago: A Systematic Review and Meta-Analysis.

This systematic review evaluated the effectiveness and side effects of various COVID-19 vaccines, with a focus on Trinidad and Tobago. The Pfizer-BioNTech and Moderna vaccines demonstrated the highest efficacy, particularly against COVID-19 variants, while Janssen and Sinopharm were comparatively less effective. mRNA vaccines, such as Pfizer-BioNTech and Oxford-AstraZeneca, were associated with more frequent and severe side effects, including soreness, fever, and cardiovascular issues.

Interconnected microbiomes-insights and innovations in female urogenital health.

The paradigm that the vaginal microbiota is a protective gateway for the urinary and reproductive systems has endured for more than a century and driven decades of probiotic research. Evidence robustly supports the notion that healthy urogenital microbiomes are predominantly colonized by lactobacilli, particularly Lactobacillus crispatus, which can acidify the local environment and protect against urogynecologic pathogen colonization. However, recent studies are beginning to delve deeper into the intricate mechanistic interactions connecting the microbiome, its diverse functional potential, host immunity, pathogens, and the development of urogenital diseases.

A new species of planthopper in the genus Melanoliarus (Hemiptera: Auchenorrhyncha: Fulgoroidea: Cixiidae) from coconut palms (Cocos nucifera) in Trinidad.

During a survey in Trinidad and Grenada for putative vectors of palm lethal decline phytoplasmas, three species of planthopper in the genus Melanoliarus (Hemiptera, Cixiidae) were collected. Melanoliarus maidis was collected from coconut palms in Grenada, M. kindli was collected from grasses in a coconut plot in Trinidad and a new species of Melanoliarus was collected from coconut palms in Trinidad.

The African-centric P47S Variant of Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition.

Unlabelled: The tumor suppressor is the most frequently mutated gene in cancer and is mutationally inactivated in 50% of sporadic tumors. Inactivating mutations in also occur in Li Fraumeni syndrome (LFS). In addition to germline mutations in in LFS that completely inactivate this protein, there are many more germline mutant forms of in human populations that partially inactivate this protein: we call these partially inactivating mutations "hypomorphs.

HSP70 inhibition blocks adaptive resistance and synergizes with MEK inhibition for the treatment of NRAS-mutant melanoma.

Unlabelled: NRAS-mutant melanoma is currently a challenge to treat. This is due to an absence of inhibitors directed against mutant NRAS, along with adaptive and acquired resistance of this tumor type to inhibitors in the MAPK pathway. Inhibitors to MEK (mitogen-activated protein kinase kinase) have shown some promise for NRAS-mutant melanoma.