Immunogenetic factors involved in the pathogenesis of distinct clinical manifestations of schistosomiasis japonica in the Philippine population.

Immunogenetic factors were studied in 60 patients with schistosomiasis japonica in the Philippines, of whom 15 were characterized by marked hepatosplenic lesions and 45 characterized by cerebral symptoms. Immune responsiveness of the patients to schistosomal antigen was measured by T cell proliferation in vitro, and their HLA-A and -B specificities were typed. All but one hepatosplenic patients showed strong immune responsiveness to the schistosomal antigen, whereas both low and high responders were observed in the cerebral patients.

An attempt to study the case fatality rate in Schistosoma japonicum infection in the Philippines.

As a sequence to a cross-sectional study on the clinical gradient of the disease by Pesigan et al., (1965) a follow-up of the subjects in that study was made after 12 years. Of the 135 untreated cases followed up, 23 (17.

Longitudinal study on Schistosoma japonicum infections in the Philippines. 4. Effect of mass-chemotherapy with praziquantel on incidence at Dagami, Leyte.

The effect of selective mass-chemotherapy with praziquantel at a dose of 60 mg/kg a day on the annual incidence of Schistosoma japonicum infection was examined by a follow-up study of 1,800 school children enrolled at 9 primary schools at Dagami Area, Leyte, Philippines. The incidence rates before mass-chemotherapy were 22.2, 24.