Publications by authors named "J S Nirwan"

Electrically tunable lenses (ETLs) are those with the ability to alter their optical power in response to an electric signal. This feature allows such systems to not only image the areas of interest but also obtain spatial depth perception (depth of field, DOF). The aim of the present study was to develop an ETL-based imaging system for quantitative surface analysis.

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Overactive bladder syndrome (OAB) is characterised by urgency symptoms, with or without urgency incontinence, usually with frequency and nocturia and severely affects the quality of life. This systematic review evaluates the various drug delivery strategies used in practice to manage OAB. Advanced drug delivery strategies alongside traditional strategies were comprehensively analysed and comparatively evaluated.

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Hypertensive crisis (HC) is an emergency health condition which requires an effective management strategy. Over the years, various researchers have developed captopril based fast-dissolving formulations to manage HC; however, primarily, the question of personalisation remains unaddressed. Moreover, commercially these formulations are available as in fixed-dose combinations or strengths, so the titration of dose according to patient's prerequisite is challenging to achieve.

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Rheumatoid arthritis (RA) is an autoimmune disease associated with severe joint pain. Herein, we report lornoxicam loaded cellulosic microsponge gel formulation with sustained anti-inflammatory effects that are required to manage arthritic pain. The microsponges were formulated using quasi emulsion-solvent diffusion method employing four different surfactant systems, namely polyvinyl alcohol (PVA), Tween80, Gelucire 48/16 and Gelucire 50/13.

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Article Synopsis
  • Mucoadhesion-based drug delivery systems are gaining traction for their ability to enhance the duration of drug action at mucosal surfaces, improving patient compliance and convenience.
  • However, testing mucoadhesion is complicated due to a lack of standardized methods and difficulties in conducting multiple measurements simultaneously, often leading to subjective results.
  • The study introduces a new technique called MUCO-DIS, using AFM to measure mucoadhesion force, surface topography, polymer dissolution, and drug release characteristics together, demonstrating its effectiveness with pectin microparticles and various gastrointestinal mucosal surfaces.
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