Publications by authors named "J S Nakagawa"
Purpose: Nivolumab plus ipilimumab (Nivo-Ipi) combination therapy is an effective first-line treatment for advanced non-small cell lung cancer (NSCLC). However, its effectiveness and feasibility in elderly patients (aged ≥ 75 years) remain unclear. This study aimed to investigate the efficacy and safety of first-line Nivo-Ipi therapy in elderly patients with NSCLC.
View Article and Find Full Text PDFFocal cortical dysplasias (FCDs) are local malformations of the human neocortex and a leading cause of intractable epilepsy. FCDs are classified into different subtypes including FCD IIa and IIb, characterized by a blurred gray-white matter boundary or a transmantle sign indicating abnormal white matter myelination. Recently, we have shown that myelination is also compromised in the gray matter of FCD IIa of the temporal lobe.
View Article and Find Full Text PDFBackground: Cerebrospinal fluid (CSF) leakage frequently complicates endoscopic endonasal transsphenoidal pituitary resections, despite the use of lumbar drains, nasoseptal flaps, or commercial dura sealants. Managing this complication often requires revision surgery and increases the risk of infection. Platelet-rich fibrin (PRF), an affordable autologous biomaterial derived from the patient's blood through short, angulated centrifugation, contains growth factors and leukocytes embedded in a fibrin matrix.
View Article and Find Full Text PDFArticle Synopsis
- - Edoxaban, a factor Xa inhibitor, is usually metabolized into an active metabolite called M-4, which has minimal antithrombotic effects in healthy individuals; however, certain conditions can elevate its plasma concentration significantly.
- - A 68-year-old man with pancreatic cancer was prescribed edoxaban along with rifampin and clarithromycin for lung disease but developed acute kidney injury after surgery, leading to unusually high levels of M-4 in his system.
- - This case highlights the potential for increased M-4 levels in patients with kidney issues who are taking edoxaban alongside drugs that affect its metabolism, suggesting that these combinations could be more clinically impactful than previously understood.
Objective: To evaluate the usefulness of gasless reduced-port laparoscopic myomectomy (GRP-LM) using a subcutaneous abdominal wall lifting method.
Methods: In GRP-LM, after lifting the abdominal wall by a subcutaneous abdominal wall lifting method, a 1.5-cm incision is made in the lateral abdomen, Lap Protector is placed.