Publications by authors named "J S Mogil"
Chronic pain is a leading cause of disability, affecting more women than men. Different immune cells contribute to this sexual divergence, but the mechanisms, especially in females, are not well defined. We show that pannexin-1 (Panx1) channels on microglia and T cells differentially cause mechanical allodynia, a debilitating symptom of neuropathic pain.
View Article and Find Full Text PDFChronobiological approaches have emerged as tools to study pain and inflammation. Although time-of-day effects on the expression of pain after injury have been studied, it remains unaddressed whether the timing of the injury itself can alter subsequent pain behaviors. The aim of this study was to assess postsurgical pain behaviors in a mouse hind paw incision assay in a circadian-dependent manner.
View Article and Find Full Text PDFFacial grimacing is used to quantify spontaneous pain in mice and other mammals, but scoring relies on humans with different levels of proficiency. Here, we developed a cloud-based software platform called PainFace ( http://painface.net ) that uses machine learning to detect 4 facial action units of the mouse grimace scale (orbitals, nose, ears, whiskers) and score facial grimaces of black-coated C57BL/6 male and female mice on a 0 to 8 scale.
View Article and Find Full Text PDFArticle Synopsis
- Spinal nociceptive circuits become sensitized in neuropathic pain, largely influenced by gene expression changes through transcriptional and translational controls.
- The study indicates that during chronic neuropathic pain, it's primarily translational regulation that impacts gene expression in the spinal cord.
- Findings show that regulating translation in specific spinal neurons, particularly inhibitory ones, significantly affects pain sensitivity, with increased translation in these neurons linked to heightened hypersensitivity.