Publications by authors named "J S Miser"
Background: Myeloablative, high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT) improves outcome in some high-risk malignant solid tumors and lymphomas in children and young adults.
Methods: We performed 16 peripheral blood stem cell (PBSC) harvests in 12 children and 2 young adult patients with a high-risk malignant solid tumor or refractory/relapsed Hodgkin's lymphoma from August 2015 to December 2020. In our chemotherapy mobilization protocol, we used an absolute neutrophil count (ANC) of >1 × 10/L following the nadir after chemotherapy as the criterion for undertaking the apheresis.
An Infant-Type Hemispheric Glioma With SOX5::ALK: A Novel Fusion.
J Natl Compr Canc Netw
February 2024
Infant-type hemispheric glioma (IHG) is a rare pediatric brain tumor with variable response to chemotherapy and radiotherapy. Molecular insights into IHG can be useful in identifying potentially active targeted therapy. A male fetus was found to have congenital hydrocephalus at the gestational age of 37 weeks.
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- A study was conducted on twelve Asian patients with various types of sarcoma who received interval-compressed chemotherapy, alternating between two specific drug regimens (VDC and IE), with support from filgrastim and carboplatin for certain cases.
- The treatment included a total of 129 cycles, with a median interval of 19 days between cycles, and showed that patients had manageable side effects, like neutropenia and low platelet counts, with a notable percentage experiencing fever.
- Out of the nine patients with measurable tumors, seven showed a positive response to the treatment, indicating that this chemotherapy approach is feasible for Asian children and young adults with sarcoma.