Publications by authors named "J S Merrin"
Article Synopsis
- The study investigates how dynamic changes in Bone Morphogenetic Protein (BMP) signaling contribute to the diversity of cell types in the developing mouse neural tube, using a specialized embryonic stem cell differentiation system.* ! -
- Researchers observed that differentiating cells self-organize into specific patterns of dorsal neural tube cell types, driven by distinct phases of BMP signaling both in lab conditions and in living mice.* ! -
- A modeling approach revealed that the BMP signaling dynamics involve a unique temporal relay mechanism, combining fast negative feedback and slow positive regulation, which supports precise control over sequential cell type generation in developing tissues.* !
Geometrically controlled stem cell differentiation promotes reproducible pattern formation. Here, we present a protocol to fabricate elastomeric stencils for patterned stem cell differentiation. We describe procedures for using photolithography to produce molds, followed by molding polydimethylsiloxane (PDMS) to obtain stencils with through holes.
View Article and Find Full Text PDFBackground: Eating disorders (EDs) are serious, often chronic, conditions associated with pronounced morbidity, mortality, and dysfunction increasingly affecting young people worldwide. Illness progression, stages and recovery trajectories of EDs are still poorly characterised. The STORY study dynamically and longitudinally assesses young people with different EDs (restricting; bingeing/bulimic presentations) and illness durations (earlier; later stages) compared to healthy controls.
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