The effect of minimally invasive surgery on thirty-day postoperative outcomes of frail patients undergoing emergency colon resections.

Background: Frail patients have poor outcomes after emergent colon surgery. While minimally invasive surgery has shown improved outcomes in the general patient population undergoing colectomy, the benefits in frail patients are unknown.

Methods: We identified frail patients who underwent urgent or emergent colon resections from 2017 to 2021 in the National Surgical Quality Improvement Program database.

Plasma transfusion in the intensive care unit.

Background: Current guidelines discourage prophylactic plasma use in non-bleeding patients. This study assesses global plasma transfusion practices in the intensive care unit (ICU) and their alignment with current guidelines.

Study Design And Methods: This was a sub-study of an international, prospective, observational cohort.

Incorporating the concept of overtransfusion into hemovigilance monitoring: An expert-based definition and criteria from the International HIT-OVER Forum.

Background: Liberal or overtransfusion (OT) may be regarded as "inappropriate," but it is not reported as a transfusion-related adverse event. A definition of OT is lacking. OT may include overdosing of components, giving the incorrect component, or unnecessary administration without evidence of need for transfusion.

Homeodynamic feedback inhibition control in whole-brain simulations.

Simulations of large-scale brain dynamics are often impacted by overexcitation resulting from heavy-tailed structural network distributions, leading to biologically implausible simulation results. We implement a homeodynamic plasticity mechanism, known from other modeling work, in the widely used Jansen-Rit neural mass model for The Virtual Brain (TVB) simulation framework. We aim at heterogeneously adjusting the inhibitory coupling weights to reach desired dynamic regimes in each brain region.