Publications by authors named "J S McCombs"

Article Synopsis
  • Tlr7 deficiency is linked to more severe COVID-19 due to lower production of interferons (IFNs), which are important for the immune response.
  • Infected mice show that the virus activates Tlr7 and IFN pathways initially; however, Tlr7 and Irf7 deficiencies lead to worse symptoms and higher viral loads.
  • Deficiencies in Tlr7 and Irf7 result in reduced antibody production against SARS-CoV-2, hindering the body's ability to clear the virus effectively.
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Objectives: Medication persistence in type 2 diabetes (T2D) is a critical factor for preventing adverse clinical events. We assessed persistence among newly treated patients with T2D and documented the impact of persistence on clinical outcomes and costs.

Study Design: Retrospective study of Optum Clinformatics Data Mart commercial and Medicare Advantage enrollees from 2007 to 2020.

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Lung tissue resident memory (TRM) cells are thought to play crucial roles in lung host defense. We have recently shown that immunization with the adjuvant LTA1 (derived from the A1 domain of E. coli heat labile toxin) admixed with OmpX from K.

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: Develop corridor-level network screening models to identify high-risk corridors where safety improvements could be implemented to reduce fatal and injury (FI) crashes. : A novel corridor definition focused on context classification and lane count was developed and applied to urban and suburban four-lane divided arterial roadways in Florida. Negative binomial regression models were developed for multi- and single-vehicle crashes using 80% of the corridors (training set).

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