Publications by authors named "J S Marron"
Synthesis and crystal structures of five fluorinated diphenidine derivatives.
Acta Crystallogr E Crystallogr Commun
March 2025
Diphenidine (), a dissociative anaesthetic, was first reported in 2013. Since then, a number of derivatives 2-methoxphenidine () have been produced by clandestine laboratories and sold as . Fluorinated diphenidines, namely, [1-(2,6-di-fluoro-phen-yl)-2-phenyl-eth-yl]di-methyl-aza-nium chloride, CHFN·Cl, (), [1-(2,6-di-fluoro-phen-yl)-2-phenyl-eth-yl](eth-yl)aza-nium chloride di-chloro-methane hemisolvate, 2CHFN·2Cl·CHCl, (), -but-yl[1-(2,6-di-fluoro-phen-yl)-2-phenyl-eth-yl]aza-nium chloride, CHFN·Cl, (), 1-[1-(2,6-di-fluoro-phen-yl)-2-phenyl-eth-yl]pyrrolidin-1-ium chloride, CHFN·Cl, (), and 1-[1-(2,3,4,5,6-penta-fluoro-phen-yl)-2-phenyl-eth-yl]piperidin-1-ium chloride, CHFN·Cl, (), were synthesized and structurally characterized by H, C and F NMR spectroscopy, and single-crystal X-ray diffraction.
View Article and Find Full Text PDFMotivation: Hi-C technology has been developed to profile genome-wide chromosome conformation. So far Hi-C data have been generated from a large compendium of different cell types and different tissue types. Among different chromatin conformation units, chromatin loops were found to play a key role in gene regulation across different cell types.
View Article and Find Full Text PDFArticle Synopsis
- Neoadjuvant radiotherapy is crucial for treating locally advanced rectal cancer, and this study compares the quality-of-life outcomes between two techniques: three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT).
- A phase II randomized trial involved 94 patients who received chemoradiotherapy and were assigned to either 3DCRT or IMRT; their quality of life was assessed using specific questionnaires throughout the treatment and at a six-month follow-up.
- Although the trial ended early due to the futility of its primary endpoint, the results indicated that while emotional functioning improved, other aspects of quality of life declined; notably, IMRT showed better physical and role functioning during the final week
The widely distributed MutS gene family functions in recombination, DNA repair, and protein translation. Multiple evolutionary processes have expanded this gene family in plants relative to other eukaryotes. Here, we investigate the origins and functions of these plant-specific genes.
View Article and Find Full Text PDF