Publications by authors named "J S Manohar"
Article Synopsis
- Pancreatic acinar cell carcinoma (PACC) is a rare and aggressive tumor with few treatment options beyond surgery, prompting a study of its genomic features.
- The research involved whole-genome and RNA sequencing of samples from 3 metastatic PACC patients, revealing markers of homologous recombination deficiency (HRD) linked to BRCA1/2 and FANCL mutations, which showed positive responses to PARP inhibitors.
- The study also identified significant structural variants and alterations in key pathways, suggesting potential targets for targeted therapies and emphasizing the need for genomic profiling to customize treatment for better outcomes.
Background: Adenocarcinoma of the esophagus and stomach demands a deeper molecular understanding to advance treatment strategies and improve patient outcomes. Here, we profiled the genome and transcriptome landscape of these cancers, explored molecular characteristics that are undetectable by other sequencing platforms, and analyzed their potential clinical ramifications.
Methods: Our study employed state-of-the-art integrative analyses of whole genome and transcriptome sequencing on 51 matched tumor and germline samples from 46 patients.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the digestive tract. Despite multiple therapeutic advances, patients with advanced disease frequently develop resistance to tyrosine kinase inhibitors (TKIs), and therefore represent a therapeutic challenge. We employed whole genome sequencing (WGS) on three metastatic GISTs refractory to various TKIs and explored a publicly available cohort of 499 GISTs.
View Article and Find Full Text PDFBackground: Advanced-stage tube-ovarian cancers (TOC) and uterine cancers (UC) significantly contribute to cancer mortality. While surgery achieves clinical remission in most cases, recurrence often necessitates systemic therapy. Recent molecular phenotype studies have advanced targeted therapies.
View Article and Find Full Text PDFArticle Synopsis
- * Key mutations were identified in various genes, such as APC and TP53, with significant genomic alterations including a unique RAD51 biallelic deleterious translocation linked to homologous recombination deficiency.
- * The research also found no major differences in mutation load or genetic features between traditional and oncocytic ACC subtypes, revealing a broad range of genomic changes that may help guide future cancer treatment options.