Using Quantitative EEG to Stratify Epilepsy Risk After Neonatal Encephalopathy: A Comparison of Automatically Extracted Features.

Purpose: Neonatal encephalopathy (NE) is a commonly encountered, highly morbid condition with a pressing need for accurate epilepsy prognostication. We evaluated the use of automated EEG for prediction of early life epilepsy after NE treated with therapeutic hypothermia (TH).

Methods: We conducted retrospective analysis of neonates with moderate-to-severe NE who underwent TH at a single center.

General Movements Assessment and Hammersmith Infant Neurological Examination for early diagnosis of cerebral palsy in infants born at term treated with therapeutic hypothermia.

Aim: To establish if the General Movements Assessment (GMA) and Hammersmith Infant Neurological Examination (HINE) support the early diagnosis of cerebral palsy (CP) in a cohort of infants who have undergone therapeutic hypothermia.

Method: This was a retrospective cohort study from a large single center between 2018 and 2022. Sample size included surviving 112 infants with follow-up (68 males, 44 females) with a mean gestational age of 39 weeks (interquartile range 38-40), diagnosed with moderate or severe neonatal encephalopathy who underwent therapeutic hypothermia.

Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of HO.

Differences in cancer and normal cell oxidative metabolism provide a unique therapeutic opportunity for developing combined modality approaches with redox-active small molecules as radio-chemosensitizers that are well-tolerated by normal tissues. Pentaazamacrocyclic Mn (II)-containing (MnPAM) superoxide dismutase (SOD) mimetics and pharmacological ascorbate given IV to achieve [mM] plasma levels (pharmacological ascorbate: P-AscH‾) have been shown to act individually as cancer cell radio- and chemosensitizers via the generation of HOin vivo. The current study shows that the combination of newly developed MnPAM dismutase mimetic, rucosopasem manganese (RUC) with P-AscH‾ radio-sensitizes non-small cell lung cancer cells (NSCLC) and increases steady state levels of intracellular HO with no additional toxicity to normal human bronchial epithelial cells (HBECs).

Pre-vascularisation of the acellular bladder matrix using the omentum in a porcine model prior for bladder reconstruction-a step towards clinical application?

Aim: Research studies with porcine acellular bladder matrix (PABM) showed integration of only small sized stamps in recipient bladders, however for clinical use in bladder augmentation significantly larger patches are needed. We hypothesised pre-vascularisation with omentum may be a step towards clinical translation.

Method: Eight domestic pigs were operated three times 8-10 weeks apart: 1-Implantation; PABM with recorded dimensions were sutured around a tissue expanding device, wrapped in omentum and sutured to the anterior abdominal wall.

A Comparison of Treatment Practices for Newborn Seizure Management Across Level II and III Neonatal Intensive Care Units in the United States.

Background: Neonatal seizures (NS) represent an important clinical manifestation among critically ill infants and are often the first sign of underlying brain injury. Early recognition and treatment are essential to reduce morbidity and mortality. The present study investigated the NS management and treatment approaches employed by level II/III neonatal intensive care units (NICUs) across the United States to identify areas of consensus and variability.