Publications by authors named "J S Karthik"
Article Synopsis
- The editorial discusses brain metastasis (BM) in breast cancer (BC), highlighting its prevalence as the second most common cancer to exhibit BM after lung cancer.
- Key risk factors for developing BM include HER-2 positive status, triple-negative BC, germline mutations, and certain demographic elements like age and ancestry.
- There is a need for validated predictive models to enhance clinical screening and treatment strategies for BM in BC, as current guidelines do not recommend routine screening and BM significantly impacts patients' quality of life.
This editorial will focus on tumor immunity and the factors that alter the tumor immune micro-environment. The role of tumor infiltrating lymphocytes (TILs) will also be discussed in detail, including the types, mechanism of action, and role. Gastric cancer (GC) often presents in the advanced stage and has various factors predicting the outcomes.
View Article and Find Full Text PDFBackground: The use of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors for breast cancer (BC) therapy is the subject of debate, and there is an urgent need to understand much the expression and prognostic role of the PARP1 protein. In this study, we have compared the expression of PARP between BC and benign breast disease (BBD) patients and also analyzed the association of PARP expression with clinicopathological parameters in BC.
Methods: The study consists of 30 patients with newly diagnosed operable BC who were planned for surgery without neoadjuvant chemotherapy and 15 patients of BBD as a control between 2019 and 2021.
Factors associated with pathologic complete response following neoadjuvant chemoradiation and esophagectomy for carcinoma of esophagus and gastroesophageal junction.
J Surg Oncol
January 2023
Background And Objectives: The aim of this study was to analyze factors associated with pathologic complete response (pCR) following neoadjuvant chemoradiation (NCRT) and esophagectomy for carcinoma of the esophagus (EC) and gastroesophageal junction (GEJ).
Methods: Patients with EC and GEJ tumors who received NCRT and underwent esophagectomy between January 2010 to March 2021 were included. Univariate and multivariate analyses were performed to evaluate the factors associated with pCR by comparing the patients who achieved pCR (pCR group) with those who did not achieve pCR (non-pCR group).
The global outbreak of Novel Corona Virus 2019 (SARS-CoV-2) has made worldwide lockdown including India since March 24, 2020. The current research aims at the improvements of nitrogen dioxide (NO) during the COVID-19 lockdown in India. This research has been done using both the open source data sets taken from satellite and ground based for better analysis.
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