Isavuconazole in the Treatment of Chronic Forms of Coccidioidomycosis.

Coccidioidomycosis is a fungal infection with a range of clinical manifestations. Currently used antifungal agents exhibit variable efficacy and toxicity profiles that necessitate evaluation of additional therapeutic options. Improvement was observed in the majority of patients treated with isavuconazole, with clinical failures observed only in those with coccidioidal meningitis.

Observing the Ocean Submesoscale with Enhanced-Color GOES-ABI Visible Band Data.

Ocean color remote sensing has long been utilized as a fundamental research tool in the oceanographic investigations of coupled biological-physical processes. Despite numerous technical advances in the application of space borne ocean-viewing radiometers, host satellite platforms in a polar-orbiting configuration often render the temporal frequency of sensor data acquisition insufficient for studies of ocean processes that occur within increasingly smaller space-time scales. Whereas geostationary ocean color missions are presently the exception (GOCI) rather than the rule, this paper presents a method to convolve ocean reflectance data obtained from contemporary ocean-viewing multispectral radiometers (VIIRS, OLCI) with spectrally-limited Advanced Baseline Imager (ABI) data obtained from the GOES-R meteorological satellites.

Treatment of Polymicrobial Osteomyelitis with Ceftolozane-Tazobactam: Case Report and Sensitivity Testing of Isolates.

Stenotrophomonas maltophilia is an inherently multidrug resistant (MDR) opportunistic pathogen with many mechanisms of resistance. SENTRY studies reveal decreasing sensitivities of S. maltophilia to trimethoprim-sulfamethoxazole and fluoroquinolones.

Cross-reactivity between voriconazole, fluconazole and itraconazole.

What Is Known And Objective: Hypersensitivity to triazoles is a rare occurrence and cross-reactivity between agents is unknown. We present a successful voriconazole challenge in a patient allergic to fluconazole and itraconazole.

Case Summary: A 41-year-old immunocompetent male with coccidioidomycosis developed fever, eosinophilia and maculopapular rash from fluconazole.