Trajectories of Chinese adolescent depression before and after COVID-19: A cross-temporal meta-analysis with segmented regression.

Background: The COVID-19 pandemic has had a profound impact on adolescent mental health, particularly in China. However, there is a lack of research examining the trends in depressive symptom levels among Chinese adolescents before and after the pandemic. This study aims to investigate the changes in depressive symptom levels among Chinese adolescents pre- and post-pandemic and to identify the factors influencing these changes.

A Doped Surface Ionization Method for Ion Mobility Spectrometry.

Rationale: Exhaled breath can be used for early warning of disease, with organic nitrogen compounds, including triethylamine (TEA), being linked to various medical conditions. Surface ionization ion mobility spectrometry (SI-IMS) facilitates the direct detection of TEA in exhaled breath. However, the presence of multiple ionization products of TEA poses challenges for both quantitative and qualitative analyses.

High-throughput Design of Single-atom Catalysts with Nonplanar and Triple Pyrrole-N Coordination for Highly Efficient H2O2 Electrosynthesis.

Single-atom catalysts (SACs) with nonplanar configurations possess unique capabilities for tailoring the oxygen reduction reaction (ORR) catalytic performance compared with the ones with planar configurations, owing to the additional orbital rearrangement arising from the asymmetric coordination atoms. However, the systematic investigation of these nonplanar SACs has long been hindered by the difficulty in screening feasible nonplanar configurations and precisely controlling the coordination structures. Herein, we demonstrate a combined high-throughput screening and experimental verification of nonplanar SACs (ppy-MN3) for highly active and selective 2e- ORR electrocatalysis.

[The distributions of serum HBsAg level in chronic hepatitis B patients based on the China Registry of Hepatitis B (CR-HepB)].

To determine the distributions of serum HBsAg level in treatment-naive or treatment-experienced chronic hepatitis B (CHB) patients. Based on the China Registry of Hepatitis B (CR-HepB), a nationwide hospital-based electronic platform, treatment-naive or treatment-experienced CHB patients who receive nucleos(t)ide analog (NA) therapy were enrolled in our study. We collected patients' clinical characteristics, including demographic, virological and biochemical data.

Deep learning radiomics on grayscale ultrasound images assists in diagnosing benign and malignant of BI-RADS 4 lesions.

This study aimed to explore a deep learning radiomics (DLR) model based on grayscale ultrasound images to assist radiologists in distinguishing between benign breast lesions (BBL) and malignant breast lesions (MBL). A total of 382 patients with breast lesions were included, comprising 183 benign lesions and 199 malignant lesions that were collected and confirmed through clinical pathology or biopsy. The enrolled patients were randomly allocated into two groups: a training cohort and an independent test cohort, maintaining a ratio of 7:3.