Publications by authors named "J S Horng"

Acidification of freshwater due to human activities is a widespread environmental problem. Its effects on the sensorimotor responses of fish, particularly during embryonic stages, may affect population fitness. To address this, zebrafish embryos were exposed to water at pH 7, 5 and 4.

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Influenza A and B viruses spread out worldwide, causing several global concerns. Discovering neuraminidase inhibitors to prevent influenza A and B viruses is thus of great interest. In this work, a machine learning model was trained and tested to evaluate the ligand-binding affinity to neuraminidase.

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Numerous environmental pollutants exhibit ototoxicity and cause damage to the lateral line structures in fish, including the neuromast and its hair cells. The lateral line is used to detect hydrodynamic changes and is thought to play a significant role in aggressive interactions. Fighting behaviors in fish are crucial for establishing social hierarchy and obtaining limited resources.

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This report presents a novel anatomical variant of the second dorsal metacarpal artery (SDMA). In this unique case, the SDMA abnormally penetrates the second dorsal interosseous muscle (SDIM), dividing into two major branches. A deep dorsal branch of the SDMA (dbSDMA) is located within the SDIM and extends to the distal end of the metacarpal.

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Article Synopsis
  • Acetylcholinesterase (AChE) is a key target for Alzheimer's disease treatment, and inhibiting it could help prevent the disease.
  • A machine-learning model, along with molecular docking and dynamics, was used to identify potential AChE inhibitors from the MedChemExpress database.
  • Two specific compounds, with PubChem IDs 130467298 and 132020434, were found to effectively inhibit AChE according to the simulations and ML predictions.*
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