Publications by authors named "J S Holler"
Article Synopsis
- Major risk factors for urothelial cell carcinoma (UCC) include smoking and occupational exposures, but 30% of cases are still unexplained; pet dogs may serve as models for studying non-tobacco UCC risk due to their similar disease behavior.
- Researchers exposed human and canine urothelial cells to acrolein and inorganic arsenic to explore DNA damage, finding specific genotoxic thresholds for each substance.
- The study indicated that non-tobacco exposure to acrolein could lead to early DNA damage in both humans and dogs, warranting further investigation into these chemical exposures in relation to UCC.
Post-Transplantation Seroprotection Rates in Liver, Lung, and Heart Transplant Recipients Vaccinated Pre-Transplantation against Hepatitis B Virus and Invasive Pneumococcal Disease.
Vaccines (Basel)
September 2024
Article Synopsis
- Vaccination before solid organ transplantation (SOT) is essential because immunosuppression post-transplant affects vaccine responses, but not much is known about how effective these vaccines are afterward.
- In a study of 136 SOT recipients, only 27.9% showed protection against hepatitis B virus (HBV) and 42.6% against invasive pneumococcal disease (IPD) after transplantation despite being vaccinated before the procedure.
- Patients who had seroprotection when listed for transplantation were significantly less likely to have a non-response to both HBV and IPD, indicating that early vaccination is crucial for improving post-transplant outcomes.
Background: Vaccine breakthrough SARS-CoV-2 infections are common and of clinical and public health concern. However, little is known about the immunological characteristics of patients hospitalized due to these infections. We aimed to investigate and compare immune cell subpopulations and induced immune responses in vaccinated and non-vaccinated patients hospitalized with severe COVID-19.
View Article and Find Full Text PDFMost language use occurs in face-to-face conversation, which involves rapid turn-taking. Seeing communicative bodily signals in addition to hearing speech may facilitate such fast responding. We tested whether this holds for co-speech hand gestures by investigating whether these gestures speed up button press responses to questions.
View Article and Find Full Text PDFThe typical pattern of alternating turns in conversation seems trivial at first sight. But a closer look quickly reveals the cognitive challenges involved, with much of it resulting from the fast-paced nature of conversation. One core ingredient to turn coordination is the anticipation of upcoming turn ends so as to be able to ready oneself for providing the next contribution.
View Article and Find Full Text PDF