How social frailty is operationalized matters: Relationships with health and wellbeing in late adulthood.

Objectives: There are currently major inconsistencies in the methodological approaches used to index social frailty. The present study aimed to better understand which of these approaches may be most valuable in predicting older adult's physical health and psychological wellbeing.

Design: One hundred and thirty-three participants aged 60-90 years completed five measures commonly used to index social frailty, along with five measures of physical health, and psychological wellbeing.

Design and Implementation of a Binary Phase-Shift Keying Frequency Diverse Array: Considerations and Challenges.

The frequency diverse array (FDA) is an architecture capable of beamforming in both range and angle, improving upon the traditional phased array (PA) which can only achieve beamforming in angle. The FDA employing directional modulation (DM) for secure directional communications (SDC) can reduce bit error rates (BERs) in both range and angle, again improving upon the traditional PA which can only reduce BER in angle. In this paper, we document the challenges involved in the design and implementation of a two-element linear FDA employing fast-time binary phase-shift keying (BPSK) modulations.

Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies.

The emergence of SARS-CoV-2 variants of concern (VOCs) has greatly diminished the neutralizing activity of previously FDA-approved monoclonal antibodies (mAbs), including that of antibody cocktails and of first-generation broadly neutralizing antibodies such as S309 (Sotrovimab). In contrast, antibodies targeting cryptic conformational epitopes of the receptor binding domain (RBD) have demonstrated broad activity against emerging variants, but exert only moderate neutralizing activity, which has so far hindered clinical development. Here, we utilize in vitro display technology to identify and affinity-mature antibodies targeting the cryptic class 6 epitope, accessible only in the "up" conformation of the SARS-CoV-2 spike trimer.