Publications by authors named "J S Gunnarsson"
Article Synopsis
- Contaminated Sediments:
- Hazardous metal contaminants in sediments pose risks to humans and wildlife, and current management options are limited.
- Polonite® as a Solution:
- In lab experiments, Polonite®, an activated calcium-silicate, showed potential as a cost-effective and sustainable sorbent for capping contaminated sediments, with significant metal uptake and reduced bioavailability.
- Key Findings:
- Adding Polonite increased the sediment's capacity to hold metals like Cu, Pb, and Zn considerably, and its usage led to a substantial reduction in metal bioavailability to marine life, making it a better alternative to traditional remediation methods like dredging.
Structure-based drug design is highly dependent on the availability of structures of the protein of interest in complex with lead compounds. Ideally, this information can be used to guide the chemical optimization of a compound into a pharmaceutical drug candidate. A limitation of the main structural method used today - conventional X-ray crystallography - is that it only provides structural information about the protein complex in its frozen state.
View Article and Find Full Text PDFSediments polluted with hydrophobic organic contaminants (HOCs) and metals can pose environmental risks, yet effective remediation remains a challenge. We investigated a new composite sorbent comprising granular activated carbon (GAC) and a calcium-silicate (Polonite®, PO) for thin-layer capping of polluted sediment, with the aim to sequester both HOCs and metals. Box cores were collected in polluted Oskarshamn harbor, Sweden, and the sediments were treated with GAC and/or Polonite in a 10-week mesocosm study to measure endpoints ranging from contaminant immobilization to ecological side effects on native fauna and biogeochemical processes.
View Article and Find Full Text PDFLarge culture volumes are often required when expression constructs are particularly low-yielding or when end uses require significant amounts of material. In these cases, a single homogeneous culture is usually more convenient, in terms of both consistency of expression and labor/resource requirements, than multiple parallel cultures. Using a WAVE Bioreactor culture, volumes as high as 500L may be achieved in a single vessel.
View Article and Find Full Text PDFContext: Secondary hyperparathyroidism (SHPT) is a complication of chronic kidney disease (CKD) affecting mineral and bone metabolism and characterized by excessive parathyroid hormone (PTH) production and parathyroid hyperplasia.
Objective: The objective of this analysis was to compare the efficacy and adverse effects of extended-release calcifediol (ERC) and paricalcitol (PCT) by assessing their effect on the biomarkers PTH, calcium, and phosphate in patients with non-dialysis CKD (ND-CKD).
Methods: A systematic literature research was performed in PubMed to identify randomized control trials (RCTs).