Comparing oncologic outcomes of partial and radical nephrectomy for T2 renal cell carcinoma: a propensity score matching cohort study and an external multicenter validation.

Purpose: There is very limited evidence on the optimal surgical treatment for patients with larger T2 renal tumors. This study aims to evaluate the oncologic outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) in T2 renal cell carcinoma (RCC).

Methods: A retrospective data analysis was conducted on T2 RCC patients who underwent PN or RN between 2004 and 2019 using the SEER database, and validated with data from multiple centers in China from 2014 to 2019.

Identifying Circulating Protein Mediators in the Link Between Smoking and Abdominal Aortic Aneurysm: An Integrated Analysis of Human Proteomic and Genomic Data.

Background: Smoking is a well-established risk factor for abdominal aortic aneurysm (AAA). However, the molecular pathways underlying this relationship remain poorly understood. This study aimed to identify circulating protein mediators that may explain the association between smoking and AAA.

Comparison of the Effectiveness of Inguinal Lymphangiography and Transjugular Intrahepatic Portosystemic Shunt (TIPS) Creation in Cirrhosis-Related Chylous Ascites.

To investigate the effectiveness of ethiodized oil lymphangiography and TIPS creation in cirrhosis-related chylous ascites, ten patients were included between January 2019 and December 2023. After the failure of conservative treatment, patients received ethiodized oil lymphangiography to identify and embolize the chylous leakage first, and then the TIPS procedure was conducted. Symptoms of chylous leakage were not controlled after ethiodized oil lymphangiography, including patients' weight increase, abdominal circumference increase, and serum albumin level decrease.

Erythromycin Repurposing for Hepatocellular Carcinoma Treatment: Targeting CD24 to Enhance Anti-Tumor Immunity.

Hepatocellular carcinoma (HCC) is a malignant tumor, making up about 90% of all primary liver cancers and ranking as a top cause of cancer mortality globally. With the severe side effects of conventional radiotherapy and chemotherapy, there's an ongoing quest for less toxic treatment options. CD24, a highly glycosylated membrane surface protein, plays a role in cancer cell adhesion and metastasis.

The chromosome-level genome of Centella asiatica provides insights into triterpenoid biosynthesis.

Centella asiatica is a well-known herbal plant that makes a significant contribution to the treatment of various chronic ailments. Triterpenoid saponins are the main active components extracted from C. asiatica, which have rich pharmacological activity.