J Allergy Clin Immunol
January 2025
Background: Studies of human IgE and its targeted epitopes on allergens have been very limited. We have an established method to immortalize IgE encoding B cells from allergic individuals.
Objective: To develop an unbiased and comprehensive panel of peanut-specific human IgE mAbs to characterize key immunodominant antigenic regions and epitopes on peanut allergens to map the molecular interactions responsible for inducing anaphylaxis.
Potato is an important sector to the U.S. economy, and it created over $100 billion in economic activity in 2021.
View Article and Find Full Text PDFVenous thrombosis is a leading cause of morbidity/mortality and associated with deficiencies of the anticoagulant protein C (PC, PROC) and its cofactor, protein S (PS, PROS1). Heterozygous mutations increase the risk of adult-onset thrombosis, while homozygous mutations result in pre/neonatal lethal thrombosis. PC- and PS-deficient patient phenotypes are generally considered clinically indistinguishable.
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