Publications by authors named "J S Cramer"
How to Implement Clinical 7T MRI-Practical Considerations and Experience with Ultra-High-Field MRI.
Bioengineering (Basel)
December 2024
The implementation of clinical 7T MRI presents both opportunities and challenges for advanced medical imaging. This tutorial provides practical considerations and experiences with 7T MRI in clinical settings. We first explore the history and evolution of MRI technology, highlighting the benefits of increased signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and susceptibility at 7T.
View Article and Find Full Text PDFBackground: Patients with systemic right ventricle (SRV), either d-transposition of the great arteries following an atrial switch procedure or congenitally corrected transposition of the great arteries, develop severe right ventricular dysfunction, prompting appropriate medical therapy. However, the efficacy of beta-blockers and angiotensin receptor blockers or angiotensin-converting enzyme inhibitors (ACEI) in SRV patients is unproven.
Objectives: The objective of this study was to determine the effects of ACEI/ARB and beta-blockers on outcomes in SRV patients after accounting for likely cofounders affecting their use.
Hepatitis C virus (HCV) infection causes ~290,000 annual human deaths despite the highly effective antiviral treatment available. Several viral immune evasion mechanisms have hampered the development of an effective vaccine against HCV, among them the remarkable conformational flexibility within neutralization epitopes in the HCV antigens. Here, we report the design of epitope-focused immunogens displaying two distinct HCV cross-neutralization epitopes.
View Article and Find Full Text PDFArticle Synopsis
- An epidemiological cohort analysis was conducted using data from the Surveillance Epidemiology and End Results national cancer database (2002-2012) to examine the impact of PM (particulate matter < 2.5 microns) on head and neck cancer (HNC) incidence.
- The study found a significant link between PM exposure and HNC, particularly noting the strongest association at a 5-year lag (β=0.24, p<0.001), with additional significant associations noted for no lag and up to a 20-year lag.
- Further subgroup analysis is recommended to deepen the understanding of how PM exposure contributes to HNC development.
Objective: To reduce the rate of central line-associated bloodstream infections (CLABSI) in the M Health Fairview Neonatal Intensive Care Unit (NICU) from 2.15 infections per 1,000 central line days to less than one per 1,000 line days using process evaluation.
Methods: An interdisciplinary team used process mapping and Failure Modes and Effects Analysis (FMEA) to identify root causes and improvement opportunities in central line maintenance.