Understanding Adherence to Medication in Chronic Patients: A Comprehensive Approach for Optimization and Analysis of Structural Factors.

This study explores the multifaceted factors that influence adherence to medication in chronic diseases. Recognizing the complexity of adherence, the research involves various psychological, social and individual determinants. Advanced algorithms developed in the context of the European BEAMER project analyse a large database, revealing five important structural factors: number of medications, socioeconomic status as indicated by the deprivation index, health interactions, patient gender and presence of cardiovascular disease.

A large-scale database of T-cell receptor beta sequences and binding associations from natural and synthetic exposure to SARS-CoV-2.

We describe the establishment and current content of the ImmuneCODE™ database, which includes hundreds of millions of T-cell Receptor (TCR) sequences from over 1,400 subjects exposed to or infected with the SARS-CoV-2 virus, as well as over 160,000 high-confidence SARS-CoV-2-associated TCRs. This database is made freely available, and the data contained in it can be used to assist with global efforts to understand the immune response to the SARS-CoV-2 virus and develop new interventions.

Traumatic brain injury and disorders of consciousness.

Trauma is one of the most common causes of disorders of consciousness (DOC) worldwide. Traumatic brain injury (TBI) leads to heterogeneous, multifocal injury via focal brain damage and diffuse axonal injury, causing an acquired network disorder. Recovery occurs through reemergence of dynamic cortical and subcortical networks.

Infra-low frequency neurofeedback impact on post-concussive symptoms of headache, insomnia and attention disorder: Results of a randomized control trial.

Unlabelled: The purpose of this study was to ascertain the impact infra-low-frequency neurofeedback (ILF NFB), a new paradigm in the field, has on post-concussive symptoms of headache, sleep and attention disorders experienced by combat Veterans.

Background: ILF NFB, a non-invasive integrative health intervention, has demonstrated clinical efficacy in treating several physical and psychological conditions, including headaches, dysregulated sleep, and attentional dysfunctions. Given that 20-40 % of combat Veterans who experienced concussions during recent military operations suffer chronically from these disorders, this study aims to determine whether ILF NFB might be an effective treatment option.