Publications by authors named "J S C Verschoor"
Article Synopsis
- - Patient loss to follow-up due to expensive and centralized diagnostics for tuberculosis is a major challenge, stressing the need for a more accessible testing method.
- - Current biomarkers, specifically antibodies against mycolic acids in mycobacterial cell walls, show potential but are hard to detect with typical rapid tests because they are of low affinity.
- - Researchers have developed a new method for detecting mycolic acid antibodies using engineered monoclonal antibodies, leading to the creation of a novel lateral flow immunoassay called MALIA, which shows promise for practical tuberculosis testing.
The rising use of plastic results in an appalling amount of waste which is scattered into the environment. One of these plastics is PET which is mainly used for bottles. We have identified and characterized an esterase from Streptomyces, annotated as LipA, which can efficiently degrade the PET-derived oligomer BHET.
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- A revolutionary multivalent vaccine for African horse sickness virus (AHSV) has been developed, designed to protect against all nine serotypes using plant-produced virus-like particles (VLPs) and viral protein 2 (VP2).
- In trials with interferon α/β receptor knock-out mice, the nonavalent vaccine outperformed the current commercial vaccine, demonstrating high neutralizing antibody levels and a strong immune response.
- This research marks the first significant evidence of a nonavalent VP2-based vaccine's effectiveness, showcasing its potential safety and efficacy for future use in combating AHSV outbreaks.
The outbreak of the SARS-CoV-2 global pandemic heightened the pace of vaccine development with various vaccines being approved for human use in a span of 24 months. The SARS-CoV-2 trimeric spike (S) surface glycoprotein, which mediates viral entry by binding to ACE2, is a key target for vaccines and therapeutic antibodies. Plant biopharming is recognized for its scalability, speed, versatility, and low production costs and is an increasingly promising molecular pharming vaccine platform for human health.
View Article and Find Full Text PDFOriginating from various environmental niches, large numbers of bacterial plasmids have been found carrying heavy metal and antibiotic resistance genes, degradation pathways and specific transporter genes for organic solvents or aromatic compounds. Such genes may constitute promising candidates for novel synthetic biology applications. Our systematic analysis of gene clusters encoded on megaplasmid pTTS12 from S12 underscores that a large portion of its genes is involved in stress response to increase survival under harsh conditions like the presence of heavy metal and organic solvent.
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