Fumagillin Shortage: How to Treat Microsporidiosis in Solid Organ Transplant Recipients in 2024?

Unlabelled: Intestinal microsporidiosis caused by is an opportunistic infection that especially affects solid organ transplant (SOT) recipients. Management revolves around tapering the immunosuppressive regimen and/or using a specific anti-microsporidia treatment, but only fumagillin has demonstrated efficacy for treatment of this infection. Since fumagillin has been commercially discontinued, nitazoxanide is increasingly being used in this indication.

Cognitive impairment in young adults after cancer treatment: A descriptive correlational study on levels and associations with disease-related, psychological, and lifestyle factors.

Purpose: Young adults report challenges concerning cancer--related cognitive impairment (CRCI). This study aimed to: (1) describe cognition in young adults post-cancer treatment using self-report and performance-based measures, and (2) examine associations between cognition and relevant disease-related, psychological, and lifestyle (physical activity; PA) factors.

Methods: Forty-six young adults (M = 31.

Global change aggravates drought, with consequences for plant reproduction.

Background: The frequency and intensity of droughts are expected to increase under global change, driven by anthropogenic climate change and water diversion. Precipitation is expected to become more episodic under climate change, with longer and warmer dry spells, although some areas might become wetter. Diversion of freshwater from lakes and rivers and groundwater pumping for irrigation of agricultural fields are lowering water availability to wild plant populations, increasing the frequency and intensity of drought.

Deep learning for 3D vascular segmentation in hierarchical phase contrast tomography: a case study on kidney.

Automated blood vessel segmentation is critical for biomedical image analysis, as vessel morphology changes are associated with numerous pathologies. Still, precise segmentation is difficult due to the complexity of vascular structures, anatomical variations across patients, the scarcity of annotated public datasets, and the quality of images. Our goal is to provide a foundation on the topic and identify a robust baseline model for application to vascular segmentation using a new imaging modality, Hierarchical Phase-Contrast Tomography (HiP-CT).