Publications by authors named "J S Borde"
Reported tick-borne-encephalitis (TBE) cases have been increasing in Western Austria, but no data are available on vaccination- and infection-specific seroprevalence. This study aimed to estimate current TBEV-seroprevalence in the region and inform prevention programs by comparing anti-NS1-based-incidence rates with reported case numbers and vaccination coverage. Between December 2023 and February 2024, serum samples from 4619 blood donors in Western Austria were collected and analyzed using TBEV- and WNV-IgG-ELISA assays.
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- The West Nile Virus (WNV) is a mosquito-borne flavivirus that can cause severe infections in humans and animals, particularly affecting the central nervous system.
- Accurate diagnosis of flavivirus infections is complicated due to cross-reactive antibodies from other flaviviruses and the reliance on intricate, time-consuming virus neutralization tests.
- This study evaluated four different tests for detecting WNV-NS1-IgG antibodies, finding that while none could match the specificity of the virus neutralization test, the in-house ELISA showed the best sensitivity and specificity among the simpler options.
Background: Tick-borne encephalitis (TBE) is the most significant tick-borne disease in Europe and Asia, with more than 10,000 cases per year worldwide. A surge of reported TBE cases can be observed despite the availability of highly efficient vaccines. There is little known about the serological immune protection rate of the population in Germany.
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- The study investigates the prevalence of tick-borne encephalitis virus (TBEV) antibodies in a south-western Germany district, uncovering that many infections may remain unnoticed due to asymptomatic cases.
- Researchers analyzed blood samples from over 2,200 healthy donors and found a TBEV NS1 IgG seroprevalence of 5.6%, indicating a significant number of silent infections.
- The results showed a high estimated incidence rate of TBEV infections at approximately 283 cases per 100,000 inhabitants, far exceeding the officially reported cases.
Introduction: Autosomal-dominant polycystic kidney disease (ADPKD) is the most common genetic cause of kidney failure. Because of the heterogeneity in disease progression in ADPKD, parameters predicting future outcome are important. The disease-causing genetic variant is one of these parameters.
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