Publications by authors named "J S Ashburner"

Introduction: Increasingly, autistic adolescents and adults are accessing occupational therapy. However, limited evidence exists on the type of supports that are important to them. Examining the patterns of supports valued by autistic adolescents and adults will inform the design of occupational therapy services.

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Background: Handheld single-lead electrocardiographic (1L ECG) devices are increasingly used for atrial fibrillation (AF) screening, but their real-world performance is not well understood.

Objectives: The purpose of this study was to quantify the diagnostic test characteristics of 1L ECG automated interpretations for prospective AF screening.

Methods: We calculated the diagnostic test characteristics of the AliveCor KardiaMobile 1L ECG (AliveCor, US) algorithm using unblinded cardiologist overread as the gold standard using single 30s tracings administered by medical assistants among individuals aged ≥65 years participating in the VITAL-AF trial (NCT03515057) of population-based AF screening embedded within routine primary care.

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Article Synopsis
  • The study analyzed the VITAL-AF trial, focusing on one-time ECG screening for atrial fibrillation (AF) to see if it was effective for specific subgroups.
  • Results showed that while the screening increased AF diagnosis rates in a small group of older individuals (mean age 84, 68% female), it did not identify any subgroup where screening was consistently effective based on predicted AF risk.
  • The findings suggest that predicted AF risk is not a reliable indicator of screening effectiveness, indicating a need for caution in assuming that it can guide targeted screening efforts.
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Background: Single-lead electrocardiograms (1L ECGs) are increasingly used for atrial fibrillation (AF) detection. Automated 1L ECG interpretation may have prognostic value for future AF in cases in which screening does not result in a short-term AF diagnosis.

Objective: We sought to investigate the association between automated 1L ECG interpretation and incident AF.

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Background: Adolescence heralds the onset of considerable psychopathology, which may be conceptualized as an emergence of altered covariation between symptoms and brain measures. Multivariate methods can detect such modes of covariation or latent dimensions, but none specifically relating to psychopathology have yet been found using population-level structural brain data. Using voxelwise (instead of parcellated) brain data may strengthen latent dimensions' brain-psychosocial relationships, but this creates computational challenges.

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