Publications by authors named "J Ruth"
Multicenter Clinical Performance Evaluation of the NeuMoDx™ CT/NG Assay 2.0.
Sex Transm Dis
December 2024
Background: Given the continued increases in rates of both Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection, additional diagnostic assays may be useful in increasing access to testing for these sexually transmitted infections. We evaluated the performance of the NeuMoDx™ CT/NG Assay 2.0 on the NeuMoDx-96 and NeuMoDx-288 Molecular Systems.
View Article and Find Full Text PDFBackground: Mortality from breast cancer is principally due to tumor recurrence. Recurrent breast cancers arise from the pool of residual tumor cells, termed minimal residual disease, that survive treatment and may exist in a dormant state for 20 years or more following treatment of the primary tumor. As recurrent breast cancer is typically incurable, understanding the mechanisms underlying dormant tumor cell survival is a critical priority in breast cancer research.
View Article and Find Full Text PDFCongenital melanocytic nevus syndrome: An association between congenital melanocytic nevi and neurological abnormalities.
Semin Pediatr Neurol
October 2024
Article Synopsis
- Congenital melanocytic nevus syndrome is characterized by the presence of congenital melanocytic nevi (CMN) along with various neurosystem abnormalities, primarily due to mutations in the NRAS gene.
- CMN appears as collections of melanocytes on the skin and can be classified by size and various clinical features like location and color, while neurological issues might include seizures and developmental delays.
- Early MRI screening of the central nervous system in infants is essential for assessing potential neurological risks, and while some outcomes are favorable with normal MRI results, severe complications can arise if melanoma develops.
Article Synopsis
- Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis, and the study investigates the role of soluble CD13 (sCD13) and its signaling through the bradykinin receptor B1 (B1R) in SSc pathogenesis.
- Researchers found elevated levels of CD13, B1R, and MMP14 in skin from SSc patients, which contributed to fibrosis through signaling pathways activated by TGF-β and sCD13.
- The study concludes that targeting the sCD13-B1R axis could represent a novel and effective therapeutic strategy for treating skin fibrosis in SSc.
Article Synopsis
- Hidradenitis suppurativa (HS) is a chronic inflammatory condition that significantly increases the risk of various cancers, with the risk reaching up to 50% in patients.
- A systematic review examined 443 initial publications, identifying 25 studies that showed a correlation between the severity of HS and the likelihood of specific malignancies like oropharyngeal, colorectal, and skin cancers.
- Complicated malignant transformations can occur in severe HS cases, leading to cutaneous squamous cell carcinoma (cSCC), but the underlying mechanisms for these changes are still not fully understood.