Publications by authors named "J Ruiz-Martinez"
Leucine-rich repeat kinase 2 (LRRK2) inhibition is a promising disease-modifying therapy for LRRK2-associated Parkinson's disease (L2PD) and idiopathic PD (iPD). However, pharmaco-dynamic readouts and progression biomarkers for clinical trials aiming for disease modification are insufficient since no endogenous marker reflecting enhanced kinase activity of the most common LRRK2 G2019S mutation has been reported yet in L2PD patients. Employing phospho-/proteomic analyses we assessed the impact that LRRK2 activating mutations had in peripheral blood mononuclear cells (PBMCs) from a LRRK2 clinical cohort from Spain (n=174).
View Article and Find Full Text PDFArticle Synopsis
- Understanding how nanoalloys change during reactions is crucial for developing effective catalysts.
- The study uses high-energy X-ray diffraction to observe how the structure of dual noble metal alloys changes in a proton-exchange membrane fuel cell.
- Findings indicate that an oscillatory strain in the alloy nanoparticles, linked to metal atom diffusion and partial oxidation, enhances the durability of the catalysts, offering insights for creating long-lasting electrocatalysts in fuel cells.
Given that ethanol can be obtained from abundant biomass resources (e.g., crops, sugarcane, cellulose, and algae), waste, and CO, its conversion into value-added chemicals holds promise for the sustainable production of high-demand chemical commodities.
View Article and Find Full Text PDFArticle Synopsis
- Honey bees are vital for pollination but face threats from invasive subspecies, pathogens, and parasites, highlighting the need for better identification tools.
- The introduction of HBeeID provides a powerful tool for identifying different honey bee subspecies using genomic data and diagnostic SNPs, even with incomplete samples.
- HBeeID is adaptable for future improvements and can help monitor invasive honey bee species, aiding ecological management efforts.