Hematologists/Physicians Need to Be Aware of Pseudohypercalcemia in Monoclonal Gammopathy: Lessons from a Case Report.

We present a patient at risk of misdiagnosis with multiple myeloma due to pseudohypercalcemia. Examinations showed monoclonal protein, 50% monoclonal plasma cells in bone marrow, and hypercalcemia but no osteolytic bone lesions. Follow-up tests revealed pseudohypercalcemia, with elevated total calcium, but normal ionized calcium: a discrepancy due to calcium binding to monoclonal paraprotein (confirmed by laboratory experiments).

Indirect Basophil Activation Test for Peanut Allergy Diagnosis Using Human Donor Basophils.

The basophil activation test (BAT) is a promising test for the replacement of the expensive, time-consuming, and patient-unfriendly oral food challenge (OFC). However, the BAT requires a fresh blood sample which has to be analyzed within 1 day, which can be a logistical constraint. The indirect or passive basophil activation test (iBAT) with human donor basophils and patient serum that can be stored for a long time (1) enables laboratories to perform the assay at any time, (2) gives the possibility to analyze different allergens in the course of time without the need of a new blood sample, and (3) does not suffer from inconclusive results due to nonresponder basophils.

Pollen Sensitization Can Increase the Allergic Reaction to Non-Cross-Reactive Allergens in a Soy-Allergic Patient.

During and after the pollen season, an increase in food-triggered allergic symptoms has been observed in pollen-food syndrome patients, possibly due to seasonal boosting of pollen-IgE levels. It has been suggested that consumption of birch-pollen-related foods plays a role in seasonal allergenic inflammation. However, whether this increased pollen sensitization during the pollen season can also affect the allergenicity of allergens that are non-cross-reactive with birch pollen remains in question.

The Relevance of Nutrition for Pediatric Allergy and Immunity.

The development of the immune system in early life is essential to shape an immune system [...