Publications by authors named "J Ruben"
Dental materials are challenged by wear processes in the oral environment and should be evaluated in laboratory tests prior to clinical use. Many laboratory wear-testing devices are high-cost investments and not available for cross-centre comparisons. The 'Rub&Roll' wear machine enables controlled application of force, chemical and mechanical loading, but the initial design was not able to test against rigid antagonist materials.
View Article and Find Full Text PDFLEDoxy-SL: A Placebo-Controlled, Double-Blind, Randomized, 24-Month Trial of Six Weeks of Daily Doxycycline Plus Hygiene-Based Essential Care for Reducing Progression of Filarial Lymphedema in Sri Lanka.
Am J Trop Med Hyg
October 2024
Morbidity management of filarial lymphedema remains a challenge even during the post-lymphatic filariasis elimination era in Sri Lanka despite provision of the predominantly hygiene-based WHO Essential Package of Care. Because prior studies have suggested that 6 weeks of doxycycline may reduce progression of limb lymphedema, we conducted a randomized, placebo-controlled, superiority study to evaluate this possibility in Sri Lanka. Patients aged 14 to 65 years with lymphedema in one or both legs received either 200 mg of doxycycline daily for 6 weeks or matching placebo.
View Article and Find Full Text PDFArticle Synopsis
- The WHO recommends an essential care package for filarial limb lymphedema, including daily washing and elevation, but access to comprehensive decongestive therapy (DT) is limited in low- and middle-income countries (LMICs).
- A pilot study in Galle, Sri Lanka, tested the use of self-adjustable, short-stretch compression garments (SSCG) alongside the essential care package over six weeks with ten participants suffering from advanced lymphedema.
- The study found a median limb volume reduction of 11.3% due to compression, with high acceptability of the garments, but no significant change in overall quality of life as measured by the WHODAS 2.0 scores,
Objective To evaluate the perceptions of the coronavirus disease 2019 (COVID-19) initiated workplace strategies implemented in radiation oncology departments across Australia. Methods A multidisciplinary team from Princess Alexandra Hospital developed a survey to address the impact of the pandemic strategies on areas such as patient care, staff education, well-being, flexible working arrangements, and research. The survey was conducted from November 2020 to April 2021.
View Article and Find Full Text PDFBackground: Stereotactic ablative body radiotherapy (SABR) is a novel non-invasive alternative for patients with primary renal cell cancer who do not undergo surgical resection. The FASTRACK II clinical trial investigated the efficacy of SABR for primary renal cell cancer in a phase 2 trial.
Methods: This international, non-randomised, phase 2 study was conducted in seven centres in Australia and one centre in the Netherlands.